The following publications are key project-related research outputs from Beneficiary laboratories. Where GLIORESOLVE DCs are co-authors this is clearly highlighted.
Protocol using ex vivo mouse brain slice culture mimicking in vivo conditions to study tumor growth and cell motility of glioblastoma cells
Neises L, Delbrouck C, Schuster A, Rezaipour M, Eiden K, Oudin A, Fabian C, Niclou SP, Golebiewska A, Meiser J.
STAR Protoc. 2024 Oct 18;5(4):103401. doi: 10.1016/j.xpro.2024.103401
Targeting the tumour vasculature: from vessel destruction to promotion
Guelfi S, Hodivala-Dilke K, Bergers G.
Nat Rev Cancer. 2024 Oct;24(10):655-675. doi: 10.1038/s41568-024-00736-0
The Pan-tumor Vasculature Under the Transcriptomic Magnifying Glass (1st author DC3)
Skandha Gopalan K, Bergers G.
Cancer Res. 2024 Sep 6. doi: 10.1158/0008-5472.CAN-24-3219.
BMP4 and Temozolomide Synergize in the Majority of Patient-Derived Glioblastoma Cultures
Verploegh ISC, Conidi A, El Hassnaoui H, Verhoeven FAM, Korporaal AL, Ntafoulis I, van den Hout MCGN, Brouwer RWW, Lamfers MLM, van IJcken WFJ, Huylebroeck D, Leenstra S.
Int J Mol Sci. 2024 Sep 22;25(18):10176. doi: 10.3390/ijms251810176.
A novel methylation signature predicts extreme long-term survival in glioblastoma
Decraene B, Coppens G, Spans L, Solie L, Sciot R, Vanden Bempt I, De Smet F, De Vleeschouwer S.
J Neurooncol. 2024 Sep;169(2):341-347. doi: 10.1007/s11060-024-04741-z.
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts
Yabo YA, Moreno-Sanchez PM, Pires-Afonso Y, Kaoma T, Nosirov B, Scafidi A, Ermini L, Lipsa A, Oudin A, Kyriakis D, Grzyb K, Poovathingal SK, Poli A, Muller A, Toth R, Klink B, Berchem G, Berthold C, Hertel F, Mittelbronn M, Heiland DH, Skupin A, Nazarov PV, Niclou SP, Michelucci A, Golebiewska A.
Genome Med. 2024 Apr 2;16(1):51. doi: 10.1186/s13073-024-01321-8.
An autologous ex vivo model for exploring patient-specific responses to viro-immunotherapy in glioblastoma
Eftychia Stavrakaki, Wouter B.L. van den Bossche, Lisette B. Vogelezang, Cristina Teodosio, Dana M. Mustafa, Jacques J.M. van Dongen, Clemens M.F. Dirven, Rutger K. Balvers, and Martine L. Lamfers
Cell Rep Methods. 2024 Mar 25;4(3):100716.
A clinically relevant computed tomography (CT) radiomics strategy for intracranial rodent brain tumour monitoring
Connor K, Conroy E, White K, Shiels LP, Keek S, Ibrahim A, Gallagher WM, Sweeney KJ, Clerkin J, O'Brien D, Cryan JB, O'Halloran PJ, Heffernan J, Brett F, Lambin P, Woodruff HC, Byrne AT.
Sci Rep. 2024 Feb 1;14(1):2720. doi: 10.1038/s41598-024-52960-1.
Magnetic resonance imaging-guided intracranial resection of glioblastoma tumors in patient-derived orthotopic xenografts leads to clinically relevant tumor recurrence
Oudin A, Moreno-Sanchez PM, Baus V, Niclou SP, Golebiewska A.
BMC Cancer. 2024 Jan 2;24(1):3. doi: 10.1186/s12885-023-11774-6.
Tumor-reactive T helper cells in the context of vaccination against glioma
Zhao B, Kilian M, Bunse T, Platten M, Bunse L.
Cancer Cell. 2023 Nov 13;41(11):1829-1834. doi: 10.1016/j.ccell.2023.09.013
Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers (Co-author DC1)
Ntafoulis I, Kleijn A, Ju J, Jimenez-Cowell K, Fabro F, Klein M, Chi Yen RT, Balvers RK, Li Y, Stubbs AP, Kers TV, Kros JM, Lawler SE, Beerepoot LV, Kremer A, Idbaih A, Verreault M, Byrne AT, O'Farrell AC, Connor K, Biswas A, Salvucci M, Prehn JHM, Lambrechts D, Dilcan G, Lodi F, Arijs I, van den Bent MJ, Dirven CMF, Leenstra S; GLIOTRAIN consortium; Lamfers MLM.
Br J Cancer. 2023 Oct;129(8):1327-1338. doi: 10.1038/s41416-023-02402-y.
Genomic Exploration of Distinct Molecular Phenotypes Steering Temozolomide Resistance Development in Patient-Derived Glioblastoma Cells
Fabro F, Kers TV, Feller KJ, Beerens C, Ntafoulis I, Idbaih A, Verreault M, Connor K, Biswas A, Salvucci M, Prehn JHM, Byrne AT, O'Farrell AC, Lambrechts D, Dilcan G, Lodi F, Arijs I, Kremer A, Tching Chi Yen R, Chien MP, Lamfers MLM, Leenstra S.
Int J Mol Sci. 2023 Oct 27;24(21):15678. doi: 10.3390/ijms242115678.
Comparative analysis of deeply phenotyped GBM cohorts of 'short-term' and 'long-term' survivors
Biswas A, Salvucci M, Connor K, Düssmann H, Carberry S, Fichtner M, King E, Murphy B, O'Farrell AC, Cryan J, Beausang A, Heffernan J, Cremona M, Hennessy BT, Clerkin J, Sweeney KJ, MacNally S, Brett F, O'Halloran P, Bacon O, Furney S, Verreault M, Quissac E, Bielle F, Ahmed MH, Idbaih A, Leenstra S, Ntafoulis I, Fabro F, Lamfers M, Golebiewska A, Hertel F, Niclou SP, Yen RTC, Kremer A, Dilcan G, Lodi F, Arijs I, Lambrechts D, Purushothama MK, Kel A, Byrne AT, Prehn JHM.
J Neurooncol. 2023 Jun;163(2):327-338. doi: 10.1007/s11060-023-04341-3.
Single-cell molecular profiling using ex vivo functional readouts fuels precision oncology in glioblastoma
Panovska D, Nazari P, Cole B, Creemers PJ, Derweduwe M, Solie L, Van Gassen S, Claeys A, Verbeke T, Cohen EF, Tolstorukov MY, Saeys Y, Van der Planken D, Bosisio FM, Put E, Bamps S, Clement PM, Verfaillie M, Sciot R, Ligon KL, De Vleeschouwer S, Antoranz A, De Smet F.
Cell Mol Life Sci. 2023 May 12;80(6):147. doi: 10.1007/s00018-023-04772-1.
Expression and Prognostic Value of CD80 and CD86 in the Tumor Microenvironment of Newly Diagnosed Glioblastoma
Mohammed H Ahmed, Isaias Hernández-Verdin, Franck Bielle, Maïté Verreault, Julie Lerond, Agusti Alentorn, Marc Sanson, Ahmed Idbaih
Can J Neurol Sci. 2023 Mar;50(2):234-242
Identification, validation and biological characterisation of novel glioblastoma tumour microenvironment subtypes: implications for precision immunotherapy
K White K Connor, M Meylan, A Bougoüin, M Salvucci, F Bielle, A C O'Farrell, K Sweeney, L Weng, G Bergers, P Dicker, D M Ashley, E S Lipp, J T Low, J Zhao, P Wen, R Prins, M Verreault, A Idbaih, A Biswas, J H M Prehn, D Lambrechts, I Arijs, F Lodi, G Dilcan, M Lamfers, S Leenstra, F Fabro, I Ntafoulis, J M Kros, J Cryan, F Brett, E Quissac, A Beausang, S MacNally, P O'Halloran, J Clerkin, O Bacon, A Kremer, R T Chi Yen, F S Varn, R G W Verhaak, C Sautès-Fridman, W H Fridman, A T Byrne
Ann Oncol. 2023 Mar; 34(3): 300-314.
MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors
Kilian M, Sheinin R, Tan CL, Friedrich M, Krämer C, Kaminitz A, Sanghvi K, Lindner K, Chih YC, Cichon F, Richter B, Jung S, Jähne K, Ratliff M, Prins RM, Etminan N, von Deimling A, Wick W, Madi A, Bunse L, Platten M.
Cancer Cell. 2023 Feb 13;41(2):235-251.e9. doi: 10.1016/j.ccell.2022.12.007
T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles
Turco V, Pfleiderer K, Hunger J, Horvat NK, Karimian-Jazi K, Schregel K, Fischer M, Brugnara G, Jähne K, Sturm V, Streibel Y, Nguyen D, Altamura S, Agardy DA, Soni SS, Alsasa A, Bunse T, Schlesner M, Muckenthaler MU, Weissleder R, Wick W, Heiland S, Vollmuth P, Bendszus M, Rodell CB, Breckwoldt MO, Platten M.
Nat Commun. 2023 Feb 11;14(1):771. doi: 10.1038/s41467-023-36321-6.
Low-Intensity Pulsed Ultrasound-Mediated Blood-Brain Barrier Opening Increases Anti-Programmed Death-Ligand 1 Delivery and Efficacy in Gl261 Mouse Model
Mohammed H Ahmed, Isaias Hernández-Verdin, Emie Quissac, Nolwenn Lemaire, Coralie Guerin, Lea Guyonnet, Noël Zahr, Laura Mouton, Mathieu Santin, Alexandra Petiet, Charlotte Schmitt, Guillaume Bouchoux, Michael Canney, Marc Sanson, Maïté Verreault, Alexandre Carpentier, Ahmed Idbaih
Pharmaceutics. 2023 Jan 30;15(2):455
Challenges in glioblastoma research: focus on the tumor microenvironment
Bikfalvi A, da Costa CA, Avril T, Barnier JV, Bauchet L, Brisson L, Cartron PF, Castel H, Chevet E, Chneiweiss H, Clavreul A, Constantin B, Coronas V, Daubon T, Dontenwill M, Ducray F, Enz-Werle N, Figarella-Branger D, Fournier I, Frenel JS, Gabut M, Galli T, Gavard J, Huberfeld G, Hugnot JP, Idbaih A, Junier MP, Mathivet T, Menei P, Meyronet D, Mirjolet C, Morin F, Mosser J, Moyal EC, Rousseau V, Salzet M, Sanson M, Seano G, Tabouret E, Tchoghandjian A, Turchi L, Vallette FM, Vats S, Verreault M, Virolle T.
Trends Cancer. 2023 Jan;9(1):9-27. doi: 10.1016/j.trecan.2022.09.005.
Novel kinome profiling technology reveals drug treatment is patient and 2D/3D model dependent in glioblastoma
Federica Fabro, Nynke M Kannegieter, Erik L de Graaf, Karla Queiroz, Martine L M Lamfers, Anna Ressa, Sieger Leenstra
Front Oncol. 2022 Nov 3;12:1012236
Identification of growth hormone receptor as a relevant target for precision medicine in low-EGFR expressing glioblastoma
Maïté Verreault, Irma Segoviano Vilchis, Shai Rosenberg, Nolwenn Lemaire, Charlotte Schmitt, Jérémy Guehennec, Louis Royer-Perron, Jean-Léon Thomas, TuKiet T Lam, Florent Dingli, Damarys Loew, François Ducray, Sophie Paris, Catherine Carpentier, Yannick Marie, Florence Laigle-Donadey, Audrey Rousseau, Natascha Pigat, Florence Boutillon, Franck Bielle, Karima Mokhtari, Stuart J Frank, Aurélien de Reyniès, Khê Hoang-Xuan, Marc Sanson, Vincent Goffin, Ahmed Idbaih
Clin Transl Med. 2022 Jul;12(7):e939